Therefore, people experiencing symptoms like weakness, fatigue, difficulty concentrating, and shortness of breath may benefit from getting their B12 levels checked. Your body uses vitamin B12 to make red blood cells and keep your heart, brain, and nervous system functioning optimally (18). [Ref], Rare (less than 0.1%): Allergic responses (including erythema, skin rash, itching, general malaise, respiratory difficulty due to bronchospasm), anaphylaxis (including shock)[Ref], Frequency not reported: Decreased vitamin B12 serum levels, worsening symptoms of B12 deficiency[Ref]. In turn, this could increase your risk of brain and nervous system damage. Vitamin B12, B6, and Folic Acid supplements . As such, folic acid supplements or fortified foods may cause unmetabolized folic acid (UMFA) to accumulate in your blood — something that doesn’t happen when you eat high folate foods (9, 10). Supplement dosages usually range from 400–800 mcg (1). Hardly anyone talks about folic acid side effects. Adequate folate intake during pregnancy is necessary for your baby’s brain development and reduces the risk of malformations (21, 22, 23, 24). skin rash or itching. Folate is the essential vitamin sometimes referred to as Vitamin B9, but more commonly known by its synthetic supplemental form 'folic acid'. Thus, anyone taking medications should consult a health professional before taking folic acid (1). However, high doses of folic acid can result in diarrhea, insomnia, rash, etc. Cerner Multum, Inc. "Australian Product Information." When used orally at appropriate doses, folic acid is likely safe.Oral use of folic acid can cause: 1. You're unlikely to get side effects with folic acid, but some people feel sick, lose their appetite, get wind or feel bloated. Folic acid supplements are used to reduce the risk of birth defects, as well as prevent or treat a folate deficiency. That said, excess folic acid supplement intake may cause several side effects, including slower brain development in children and accelerated mental decline in older adults. This may be particularly detrimental to people with a history of cancer. Certain minerals may also cause serious overdose symptoms if you take too much. Folic acid supplements are typically used to prevent or treat low blood folate levels. Keep in mind that more studies are needed before strong conclusions can be made. Folic acid deficiency anemia is caused by having too little folate (vitamin B9) in your blood. Bitter or bad taste, altered sleep patterns, difficulty concentrating, overactivity, and impaired judgement were reported in patients taking 15 mg folic acid daily for 1 month. Fever. While a few studies note a small increase in cancer risk in people taking folic acid supplements, most studies report no link (28, 29, 30, 31, 32). Excessive folic acid supplement intake may increase cancer cells’ ability to grow and spread, though more research is needed. Nausea 3. Sleep pattern disturbancePeople with allergies might have a reaction to folic acid supplements. Deficiency of folate is common, with studies suggesting prevalence of deficiencyas high as 85.5% as was shown in women between the ages of 16 and 49, living in the UK. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding safety information are provided O 0. But a few studies still fail to establish the effect of this supplementation on high-risk individuals ( 7 ). Toxicity caused by the drug methotrexate. Vitamin B12 Deficiency . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This damage is typically irreversible, which makes a delayed diagnosis of vitamin B12 deficiency particularly worrisome (18). If you’re pregnant or trying to conceive, you’ll need folic acid supplements. Folic Acid and Pregnancy: How Much Do You Need. When left untreated, a deficiency in this nutrient can reduce your brain’s ability to function normally and lead to permanent nerve damage. Furthermore, other research ties excessive use of folic acid supplements to mental decline (20). general weakness or discomfort. Taking folic acid seems to reduce nausea and vomiting, which are possible side effects of methotrexate treatment. Folic acid is included in most multivitamins, prenatal supplements, and B complex vitamins, but it’s also sold as an individual supplement. Cerner Multum, Inc. "UK Summary of Product Characteristics." Folic Acid Side Effects. Folate is a B vitamin. High folic acid intake may mask a vitamin B12 deficiency. Methotrexate is a common treatment for rheumatoid arthritis (RA) that can lead to folate deficiency. Folic acid is a B vitamin, and according to Elson Haas in his book “Staying Healthy With Nutrition,” a deficiency in folic acid may be the single most common vitamin deficiency. [Ref], Frequency not reported: Bitter or bad taste, altered sleep patterns, difficulty concentrating, overactivity, impaired judgement, increased incidence of seizures in some epileptic patients[Ref]. That said, they can interact with some prescription medications, including those used to treat seizures, rheumatoid arthritis, and parasitic infections. These side effects are usually mild and do not last long. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Upset stomach or throwing up. Along with its needed effects, folic acid may cause some unwanted effects. Your body breaks down and absorbs folate easier than folic acid. Conversely, vitamin B9 is called folate when it occurs naturally in foods. Folic acid and folate are two forms of vitamin B9. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Though further research is needed, it may be best to avoid taking more than the recommended daily dose of 600 mcg of folic acid supplement during pregnancy unless advised otherwise by a health professional. That said, research is mixed. Even the rare side effects of taking too much are minimal. Folic acid, otherwise referred to as folate or B9, and vitamin D are two essential vitamins for good health. Here’s why folic acid is important and how much you’ll need. In one study, 4- and 5-year-olds whose mothers supplemented with over 1,000 mcg of folic acid per day while pregnant — more than the Tolerable Upper Intake Level (UL) — scored lower on brain development tests than the children of women who took 400–999 mcg per day (16). That said, excess folic acid supplement intake may cause several side effects, including slower brain development in children and accelerated mental decline in older adults. Folic acid is a member of the vitamin B family and is important for carrying out different processes in the body. [Ref], Decreased diphenylhydantoin serum levels were reported in patients taking 5 or 15 mg folic acid daily. The Reference Daily Intake (RDI) for this vitamin is 400 mcg for most adults, though pregnant and breastfeeding women should get 600 and 500 mcg, respectively (1). Folate, also known as vitamin B9, is a water-soluble vitamin that has many important functions in your body. Learn about its functions, recommended intake, and side effects here. Itching 3. One study in healthy people over the age of 60 linked high folate levels to mental decline in those with low vitamin B12 levels — but not in those with normal B12 levels (15). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. However, they do not have the same effects on your health. Long-term vitamin B12 deficiency can lead to problems like anemia, fatigue, nerve damage and even neurological changes. When taken as per the recommended dosage, no side effects are seen as a result of taking folic acid supplements. Medically reviewed by Drugs.com. Here are 9 signs and symptoms of vitamin B12 deficiency. Find everything you need to know about folic acid (FA-8), including what it is used for, warnings, reviews, side effects, and interactions. Because many women fail to get the RDI from food alone, women of childbearing age are often encouraged to take folic acid supplements (1). We comply with the HONcode standard for trustworthy health information -, Vitamin/Mineral Supplementation and Deficiency. Folic acid supplements are generally safe and provide a convenient way to maintain adequate folate levels. O 0. This medication contains 2 ingredients: vitamin D and folic acid. Folic Acid (folic acid)." Folic acid is a synthetic form of vitamin B9 that's often added to processed foods and used in supplements. You are in RIGHT PLACE. The unlikely, minor side effects that can occur are as follows: Nausea; Cramps; Irritability; Confusion; Stomach ache; Diarrhea; Skin rash It helps make DNA and produce red blood cells. As long as the daily dose remains under 1,000 mcg daily, side effects are unlikely to occur. Another study suggests that people with high folate but low vitamin B12 levels may be up to 3.5 times likelier to experience a loss of brain function than those with normal blood parameters (19). Vitamin D 50,000 Units Side Effects Learn More Aside from potential skin rashes, taking large dosages of folic acid can cover up a vitamin B-12 deficiency because the two vitamins have overlapping functions. Taking doses of folic acid higher than 1mg can mask the symptoms of vitamin B12 deficiency, which can eventually damage the nervous system if it's not spotted and treated. respiratory difficulty due to bronchospasm. Skin rash 2. Our website services, content, and products are for informational purposes only. Your body uses folate and vitamin B12 very similarly, meaning that a deficiency in either can result in similar symptoms. Do not use medications containing calcitriol while taking vitamin D/folic acid. Applies to folic acid: capsule, solution, tablet. Folic acid also reduces the thickness of arteries, which may prevent atherosclerosis . An overdose of vitamins A, D, E, or K can cause serious or life-threatening side effects if taken in large doses. Folic acid supplements can be purchased without a prescription and are generally considered safe when taken in normal doses (37). This article examines the benefits of B-complex vitamins, as well as dosage and…. A high intake of folic acid may hasten mental decline associated with age, particularly in individuals with low vitamin B12 levels. 8. A folate deficiency can lead to complications, especially in pregnant women. Redness 4. Beans, oranges, asparagus, Brussels sprouts, avocados, and leafy greens all contain folate. Folic acid is not some major block buster drug having a list of dangerous side effects longer than its benefits. Nowadays, there are so many products of folic acid and vitamin d side effects in the market and you are wondering to choose a best one.You have searched for folic acid and vitamin d side effects in many merchants, compared about products prices & reviews before deciding to buy them. Check with your doctor as soon as possible if any of the following side effects occur while taking folic acid: Rare. It’s found exclusively in vitamins and certain fortified foods. Zinc Deficiency: The excess consumption of Folic acid create some problems in the gut and this reduces the level of Zinc intake in the person. Megaloblastic anemia is a blood disorder marked by the appearance of very large red blood cells that crowd out healthy cells, causing anemia. It is also essential in energy production of cells, metabolism of proteins, synthesis of DNA as well as in the formation of normal red blood cells. Folate and folic acid are forms of vitamin B-9. Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and phosphorus. "Product Information. The study authors cautioned that supplementing with folic acid may be detrimental to mental health in older adults with low vitamin B12 levels. 6 Effects of Folic Acid on the Brain. Keep in mind that eating lots of folate-rich foods does not appear to increase cancer risk — and may even help reduce it (35, 36). The RDI for folate is 400 mcg per day for most adults, 600 mcg per day during pregnancy, and 500 mcg per day while breastfeeding. Folate is a vital component of a healthy diet, being essential for numerous bodily functions. Having the right amount of vitamin D, calcium, and phosphorus is important for building and keeping strong bones. Because B vitamins are water soluble and the body does not store them, side effects are less likely to occur. Although not all of these side effects may occur, if they do occur they may need medical attention. Hence, 400 μg of folic acid, 2 mg of vitamin B6, and 6 μg of vitamin B12 supplement regimen are followed. High intakes of folic acid may mask a vitamin B12 deficiency. In contrast, a much smaller percentage of the folic acid you get from fortified foods or supplements gets turned into its active form in your gut (7). But according to the Harvard School of Public Health, the message is simple: Taking vitamins and supplements can be an easy way for you to get your essential nutrients, especially the ones that are lacking in most foods. However, supplementing with too much folic acid may increase insulin resistance and slow brain development in children. Loss of appetite 4. This is particularly a concern for older people because it becomes more difficult to absorb vitamin B12 as you get older. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg folic acid daily for 1 month. Method Pharmaceuticals, LLC, Arlington, TX. Folic acid is also called by the brand names Preconceive and Lexpex. Your body breaks down and absorbs folate and folic acid in slightly different ways. However, exposing cancerous cells to the vitamin may help them grow or spread (9, 26, 27). Sometimes these side effects are so intense that people stop taking methotrexate. reddened skin. All rights reserved. Folic acid’s role in cancer appears to be twofold. Moreover, pregnant women or those planning to become pregnant often take them to reduce the risk of birth defects (1). Healthline Media does not provide medical advice, diagnosis, or treatment. Here are 4 potential side effects of too much folic acid. They’re generally considered safe but may interact with some prescription drugs. Although folic acid is basically nontoxic in humans, some side effects have been reported. Folate occurs naturally in a range of foods, while folic acid is synthetic and present in fortified foods. 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